Environmental conditions are important for establishing and evaluating pre-clinical models of GVHD

Christensen, Melinda E., Sinfield, Laura J., Cullup, Hannah, Waterhouse, Nigel, Atkinson, Kerry, & Rice, Alison M. (2012) Environmental conditions are important for establishing and evaluating pre-clinical models of GVHD. Bone Marrow Transplantation, 47, pp. 607-609.

View at publisher


GVHD remains the major complication of allo-HSCT. Murine models are the primary system used to understand GVHD, and to develop potential therapies. Several factors are critical for GVHD in these models; including histo- compatibility, conditioning regimen, and T-cell number. We serendipitously found that environmental factors such as the caging system and bedding also significantly impact the kinetics of GVHD in these models. This is important because such factors may influence the experimental conditions required to cause GVHD and how mice respond to various treatments. Consequently, this is likely to alter interpretation of results between research groups, and the perceived effectiveness of experimental therapies.

Impact and interest:

1 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 82948
Item Type: Journal Article
Refereed: Yes
Additional Information: nfa
Additional URLs:
DOI: 10.1038/bmt.2011.128
ISSN: 0268-3369
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2012 Macmillan Publishers Limited
Deposited On: 30 Mar 2015 05:07
Last Modified: 02 Apr 2015 04:02

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page