Environmental conditions are important for establishing and evaluating pre-clinical models of GVHD

Christensen, Melinda E., Sinfield, Laura J., Cullup, Hannah, Waterhouse, Nigel, Atkinson, Kerry, & Rice, Alison M. (2012) Environmental conditions are important for establishing and evaluating pre-clinical models of GVHD. Bone Marrow Transplantation, 47, pp. 607-609.

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Abstract

GVHD remains the major complication of allo-HSCT. Murine models are the primary system used to understand GVHD, and to develop potential therapies. Several factors are critical for GVHD in these models; including histo- compatibility, conditioning regimen, and T-cell number. We serendipitously found that environmental factors such as the caging system and bedding also significantly impact the kinetics of GVHD in these models. This is important because such factors may influence the experimental conditions required to cause GVHD and how mice respond to various treatments. Consequently, this is likely to alter interpretation of results between research groups, and the perceived effectiveness of experimental therapies.

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ID Code: 82948
Item Type: Journal Article
Refereed: Yes
Additional Information: nfa
Additional URLs:
DOI: 10.1038/bmt.2011.128
ISSN: 0268-3369
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2012 Macmillan Publishers Limited
Deposited On: 30 Mar 2015 05:07
Last Modified: 02 Apr 2015 04:02

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