Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression

Bonda, Ulrich H., Bray, Laura J., Lister, Natalie, Ellem, Stuart, Risbridger, Gail, Freudenberg, Uwe, Werner, Carsten, Hutmacher, Dietmar, de Juan Pardo, Elena M., & Loessner, Daniela (2014) Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression. In European Association for Cancer Research (EACR) Biennial Congress, 5-8 July, 2014, Munich, Germany.

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Two-dimensional (2D) substrates cannot accurately mimic the complex matrix of native TME, whereas 3D models can recapitulate the natural tumour progression in vitro. As part of the tumour stroma, fibroblasts and endothelial cells (ECs) are well-known to not only support tumour growth but also to reduce the efficacy of anti-cancer drugs. Particularly, ECs are involved in the process of tumour vascularisation which represents a crucial step in the progression of cancer. Most of the previous studies are carried out in animal models or 2D cultures; hence, a detailed evaluation of experimental data is poor. To address this issue, we aim to develop a novel 3D in vitro approach, to mimic native tumour angiogenesis in 3D and to quantify the developed vascular network.

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ID Code: 82951
Item Type: Conference Item (Other)
Refereed: Yes
DOI: 10.1016/S0959-8049(14)50232-8
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in European Journal of Cancer. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Cancer, [VOL 50(Supplement 5), 2014] DOI: 10.1016/S0959-8049(14)50232-8
Deposited On: 30 Mar 2015 05:28
Last Modified: 30 Mar 2015 05:28

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