Developing a therapeutic anti-dendritic cell antibody to prevent graft versus host disease

Hart, Derek, Seldon, Therese, Jones, Martina, Sheng, Yonghua, Palkova, Anna, Cullup, Hannah, Munro, Trent, Sinfield, Laura, Rice, Alison M., Wilson, John, Gray, Peter, Barnard, Ross, Mahler, Stephen, & Munster, David J. (2009) Developing a therapeutic anti-dendritic cell antibody to prevent graft versus host disease. In 51st Annual Meeting of the American Society of Hematology, 5-8 December 2009, New Orleans, USA.

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Host and donor dendritic cells (DC) stimulate alloreactive donor T lymphocytes, and initiate GVHD. We have shown that polyclonal antibody to the DC surface activation marker human CD83 (anti hCD83), which depletes activated DC, can prevent human DC and T cell induced lethal xenogeneic GVHD in SCID mice without impairing T cell mediated anti-leukaemic and anti-viral (CMV and influenza) immunity (J Exp Med 2009; 206: 387). Therefore, we made and tested a polyclonal anti mouse CD83 (RAM83) antibody in murine HSCT models and developed a human mAb against hCD83 as a potential new therapeutic immunosuppressive agent.

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ID Code: 82954
Item Type: Conference Item (Other)
Refereed: Yes
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 30 Mar 2015 06:04
Last Modified: 24 Jun 2017 11:01

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