An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells
Eng, Grace Tzi Ai (2015) An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells. Masters by Research thesis, Queensland University of Technology.
The risk of prostate cancer and disease progression may potentially be increased by oxidative stress. This project examined the stability of nitroxide antioxidants and their effects on cell growth, survival and gene regulation in prostate cancer cells. The novel nitroxide, CTMIO, synthesised here at QUT, was found to have minimal toxicity and modulated the expression of a subset of oxidative stress and antioxidant-related genes distinct from those regulated by a related derivative. This study has provided a step forward in our understanding of the mechanism of action of nitroxides within cells.
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|Item Type:||QUT Thesis (Masters by Research)|
|Supervisor:||Bottle, Steven, Clements, Judith, & Dong, Ying|
|Keywords:||Prostate Cancer, Nitroxides, Oxidative Stress, Antioxidants, Cell Survival, CTMIO, PCR Arrays, Oxidative Stress and Antioxidant-Related Genes, Electron Paramagnetic Resonance|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||22 May 2015 06:28|
|Last Modified:||08 Sep 2015 06:15|
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