An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells

Eng, Grace Tzi Ai (2015) An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells. Masters by Research thesis, Queensland University of Technology.

Abstract

The risk of prostate cancer and disease progression may potentially be increased by oxidative stress. This project examined the stability of nitroxide antioxidants and their effects on cell growth, survival and gene regulation in prostate cancer cells. The novel nitroxide, CTMIO, synthesised here at QUT, was found to have minimal toxicity and modulated the expression of a subset of oxidative stress and antioxidant-related genes distinct from those regulated by a related derivative. This study has provided a step forward in our understanding of the mechanism of action of nitroxides within cells.

Impact and interest:

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

113 since deposited on 22 May 2015
70 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 82982
Item Type: QUT Thesis (Masters by Research)
Supervisor: Bottle, Steven, Clements, Judith, & Dong, Ying
Keywords: Prostate Cancer, Nitroxides, Oxidative Stress, Antioxidants, Cell Survival, CTMIO, PCR Arrays, Oxidative Stress and Antioxidant-Related Genes, Electron Paramagnetic Resonance
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 22 May 2015 06:28
Last Modified: 08 Sep 2015 06:15

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page