A novel approach to the development of benchmarking parameters for characterising cartilage health
Brown, Cameron P., Moody, Hayley R., Crawford, Ross W., & Oloyede, Adekunle (2007) A novel approach to the development of benchmarking parameters for characterising cartilage health. Connective Tissue Research, 48(1), pp. 52-61.
This paper outlines the motivation and preliminary investigations into a novel method of characterising cartilage health for potential in vivo application. Current in vivo indentation techniques, which primarily rely on stiffness measurements based on axial data, are unable to adequately distinguish between healthy and degraded tissue. The present in vitro study investigates the effects of controlled artificial degradation on the effective surface stretch, comparing the results with those obtained from the peripheral cartilage surrounding focal osteoarthritis. Results suggest that this technique is highly sensitive, showing a maximum range of 14% effective surface stretch in a normal joint compared to 42% for axial strain measurements. It is further demonstrated that the technique can discriminate between degenerative changes and the intrinsic variations in cartilage properties across the normal joint. From these investigations we propose that the relationship between indentation and the in-plane strain field under the indenter can better distinguish degraded tissue than the currently used stiffness techniques.
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|Item Type:||Journal Article|
|Keywords:||Cartilage assessment, Arthroscopic indentation, Osteoarthritis, Effective surface stretch, Cartilage degradation|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Instrumentation (090303)
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 Taylor & Francis|
|Copyright Statement:||This is an electronic version of an article published in [Connective Tissue Research 48(1):pp. 52-61.]. [Connective Tissue Research] is available online at informaworldTM|
|Deposited On:||25 Jun 2007 00:00|
|Last Modified:||29 Feb 2012 13:31|
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