Spatiotemporal analysis of indigenous and imported dengue fever cases in Guangdong province, China

Li, Zhongjie, Yin, Wenwu, Clements, Archie, Williams, Gail, Lai, Shengjie, Zhou, Hang, Zhao, Dan, Guo, Yansha, Zhang, Yonghui, Wang, Jinfeng, Hu, Wenbiao, & Yang, Weizhong (2012) Spatiotemporal analysis of indigenous and imported dengue fever cases in Guangdong province, China. BMC Infectious Diseases, 12(132).

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Dengue fever has been a major public health concern in China since it re-emerged in Guangdong province in 1978. This study aimed to explore spatiotemporal characteristics of dengue fever cases for both indigenous and imported cases during recent years in Guangdong province, so as to identify high-risk areas of the province and thereby help plan resource allocation for dengue interventions.


Notifiable cases of dengue fever were collected from all 123 counties of Guangdong province from 2005 to 2010. Descriptive temporal and spatial analysis were conducted, including plotting of seasonal distribution of cases, and creating choropleth maps of cumulative incidence by county. The space-time scan statistic was used to determine space-time clusters of dengue fever cases at the county level, and a geographical information system was used to visualize the location of the clusters. Analysis were stratified by imported and indigenous origin.


1658 dengue fever cases were recorded in Guangdong province during the study period, including 94 imported cases and 1564 indigenous cases. Both imported and indigenous cases occurred more frequently in autumn. The areas affected by the indigenous and imported cases presented a geographically expanding trend over the study period. The results showed that the most likely cluster of imported cases (relative risk = 7.52, p < 0.001) and indigenous cases (relative risk = 153.56, p < 0.001) occurred in the Pearl River Delta Area; while a secondary cluster of indigenous cases occurred in one district of the Chao Shan Area (relative risk = 471.25, p < 0.001).


This study demonstrated that the geographic range of imported and indigenous dengue fever cases has expanded over recent years, and cases were significantly clustered in two heavily urbanised areas of Guangdong province. This provides the foundation for further investigation of risk factors and interventions in these high-risk areas.

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ID Code: 83564
Item Type: Journal Article
Refereed: Yes
Keywords: Dengue fever, Spatial analysis, China
DOI: 10.1186/1471-2334-12-132
ISSN: 1471-2334
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Li et al.; licensee BioMed Central Ltd.
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 14 Apr 2015 22:43
Last Modified: 17 Apr 2015 04:46

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