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Neuronal, physiological and brain–behavioural abnormalities in opiate-addicted individuals

Yucel, Murat , Lubman, Dan I. , Harrison, Ben J. , Fornito, Alex , Wellard, R. Mark, Roffel, Kim, Clarke, Kerrie, Wood, Stephen J. , Forman, Steven D., & Pantelis, Christos (2007) Neuronal, physiological and brain–behavioural abnormalities in opiate-addicted individuals. Molecular Psychiatry, 12(7), p. 611.

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Abstract

Illustrated are the group level dorsal anterior cingulate cortex (dACC) BOLD activation maps and the spatial location of the volume localized proton-MRS (superimposed in blue) on a sagittaly oriented structural MR image (MNI, Talairach brain) for healthy controls (panel a) and opiate-dependent subject (panel b). While both groups activated the dACC to comparable levels, the opiate-using group (i) failed to show the expected correlations between dACC physiological activity and behavioural measures of control (that is, response errors) shown by the control group, (ii) had significantly increased task-related activation of fronto-parietal and cerebellar regions to achieve a comparable level of behavioural control as healthy controls and (iii) exhibited significantly reduced concentrations of N-acetylaspartate (NAA) and glutamate/glutamine (Glx) within the dACC (panel c; horizontal bars represent mean values). Taken together, these findings suggest that neuronal abnormalities and a breakdown of normal brain–behaviour relationships within the dACC of opiate addicted individuals may result in the recruitment of a compensatory network of brain regions in situations requiring behavioural control. For more information on this topic, please see the article by Yucel et al. on pp 691–702.

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ID Code: 8367
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author. Author contact details: m.wellard@qut.edu.au
DOI: 10.1038/sj.mp.4002033
ISSN: 1476-5578
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Metabolism (060104)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600) > Cell Physiology (111601)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry and Metabolomics not elsewhere classified (110199)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PHYSIOLOGY (060600) > Animal Physiology - Systems (060603)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Medical Biotechnology not elsewhere classified (100499)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Radiology and Organ Imaging (110320)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Central Nervous System (110903)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Neurochemistry (060105)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Mental Health (111714)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
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Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Nature Publishing Group
Deposited On: 02 Jul 2007
Last Modified: 11 Aug 2011 04:34

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