Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers

Zhu, Peng, Tong, Shi-Lu, Hao, Jia-Hu, Tao, Rui-Xue, Huang, Kun, Hu, Wen-Biao, Zhou, Qi-Fan, Jiang, Xiao-Min., & Tao, Fang-Biao (2015) Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers. The Journal of Nutrition, 145(6), pp. 1232-1238.

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  • Little is known about the relation between vitamin D status in early life and neurodevelopment outcomes.


  • This study was designed to examine the association of cord blood 25-hydroxyvitamin D [25(OH)D] at birth with neurocognitive development in toddlers.


  • As part of the China-Anhui Birth Cohort Study, 363 mother-infant pairs with completed data were selected. Concentrations of 25(OH)D in cord blood were measured by radioimmunoassay. Mental development index (MDI) and psychomotor development index (PDI) in toddlers were assessed at age 16–18 mo by using the Bayley Scales of Infant Development. The data on maternal sociodemographic characteristics and other confounding factors were also prospectively collected.


  • Toddlers in the lowest quintile of cord blood 25(OH)D exhibited a deficit of 7.60 (95% CI: −12.4, −2.82; P = 0.002) and 8.04 (95% CI: −12.9, −3.11; P = 0.001) points in the MDI and PDI scores, respectively, compared with the reference category. Unexpectedly, toddlers in the highest quintile of cord blood 25(OH)D also had a significant deficit of 12.3 (95% CI: −17.9, −6.67; P < 0.001) points in PDI scores compared with the reference category.


  • This prospective study suggested that there was an inverted-U–shaped relation between neonatal vitamin D status and neurocognitive development in toddlers. Additional studies on the optimal 25(OH)D concentrations in early life are needed.

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5 citations in Scopus
5 citations in Web of Science®
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ID Code: 83688
Item Type: Journal Article
Refereed: Yes
Additional Information: All journal content is made publicly accessible, without subscription, on the Journal of Nutrition website 12 months after publication. See link to publisher above.
Keywords: cord blood, vitamin D, 25-hydroxyvitamin D, infant, cognitive development
DOI: 10.3945/jn.114.208801
ISSN: 1541-6100
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 American Society for Nutrition
Deposited On: 20 Apr 2015 22:53
Last Modified: 07 Jun 2016 05:15

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