Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele
Young, Ross McD., Lawford, Bruce R., Noble, Ernest P. , Kann, Burnett , Wilkie, A., Ritchie, Terry , Arnold, Leanne, & Shadforth, Susan (2002) Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele. Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism, 37(5), pp. 451-456.
Aims: The frequency of the Taq I A alleles (A1 and A2) of the D2 dopamine receptor (DRD2) gene was examined in Caucasian post-traumatic stress disorder (PTSD) patients and controls. Results: In 91 PTSD patients, the frequency of the A1 allele was higher (P = 6.12 x 10-3) than in the 51 controls. In the 38 PTSD harmful drinkers (60 g alcohol/day), A1 allelic frequency was higher (P = 3.91 x 10-2) than in the 53 non-harmful drinkers (<60 g alcohol/day), the former being also higher (P = 3.76 x 10-4) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on DRD2 allelic association, the 35 PTSD patients with the A1+ (A1A1, A1A2) allele consumed more than twice the daily amount of alcohol than the 56 patients with the A1- (A2A2) allele (P = 1.94 x 10-3). When the hourly rate of alcohol consumed was compared, A1+ allelic patients consumed twice the rate of the A1- allelic patients (P < 10-7). Conclusion: The DRD2 A1 allele was associated with PTSD. However, this association was found only in the harmful drinkers. PTSD patients with the A1+ allele consumed more alcohol than patients with the A1- allele. The importance of determining alcohol consumption in DRD2 association studies with PTSD is suggested.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Repository Staff Only: item control page