Genotyping streptococcus pneumoniae

Rayner, Rachael, Savill, John, Hafner, Louise M., & Huygens, Flavia (2015) Genotyping streptococcus pneumoniae. Future Microbiology, 10(4), pp. 653-664.

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Abstract

Streptococcus pneumoniae is a potentially deadly human pathogen associated with high morbidity, mortality and global economic burden. The universally used bacterial genotyping methods are multilocus sequence typing and pulsed field gel electrophoresis.

However, another highly discriminatory, rapid and less expensive genotyping technique,multilocus variable number of tandem repeat analysis (MLVA), has been developed. Unfortunately, no universal MLVA protocol exists, and some MLVA protocols do not amplify certain loci for all pneumococcal serotypes, leaving genotyping profiles incomplete. A number of other genotyping or characterization methods have been developed and will be discussed. This review examines the various protocols for genotyping S. pneumoniae and highlights the current direction technology and research is heading to understand this bacterium.

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ID Code: 83975
Item Type: Review
Refereed: Yes
Keywords: Streptococcus pneumoniae, epidemiology, genotyping, MLST, MLVA
DOI: 10.2217/FMB.14.153
ISSN: 1746-0913
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Future Medicine Ltd.
Deposited On: 07 May 2015 22:57
Last Modified: 02 May 2016 18:22

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