An analysis of exosomes from keratinocytes and fibroblasts

Than, Uyen Thi Trang, Guanzon, Dominic, Wager, Lucas, Manton, Kerry J., Hollier, Brett G., & Leavesley, David I. (2015) An analysis of exosomes from keratinocytes and fibroblasts. In Vo, Van Toi & Tran, Ha Lien Phuong (Eds.) 5th International Conference on Biomedical Engineering in Vietnam, Springer, Vietnam, pp. 137-141.

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In recent years, many studies have provided evidence that exosomes secreted by cells contain various components, including microRNAs [1]. It is thought that exosomes have important roles in many biological processes. However, the role of exosomes and their components, especially miRNAs, in wound healing is poorly understood. In order to understand whether or not primary human epidermal keratinocytes and dermal fibroblasts, two important cell types contributing to wound healing process, release exosomes and what species of wound healing-associated miRNAs accumulate in these vesicles, this project will use a combination of methods to isolate and characterize exosomes, to profile exosomal cargo’s, especially miRNAs in exosomes. The results showed that keratinocytes and fibroblasts released exosomes into conditioned media and these exosomes contain some target miRNAs.

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ID Code: 84019
Item Type: Conference Paper
Refereed: Yes
Keywords: Exosomes, Keratinocytes, Fibroblasts, microRNA
DOI: 10.1007/978-3-319-11776-8_34
ISBN: 978-3-319-11776-8
ISSN: 1433-9277
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: © Springer International Publishing AG
Deposited On: 11 May 2015 03:53
Last Modified: 09 Nov 2015 04:24

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