Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment

Fuhrman-Luck, Ruth Anna (2015) Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment. PhD thesis, Queensland University of Technology.


Prostate cancer is a leading cause of male cancer-related death and novel therapies are required that prevent progression to terminal disease. This study identified novel protein targets and cell signalling pathways regulated by the prostate cancer-associated protease, kallikrein-related peptidase 4, highlighting it as a promising target for anti-cancer therapy. Seventy-five novel targets and key signalling pathways were identified to be regulated by the protease, suggesting novel functions in remodelling tumour tissue to enable prostate cancer progression.

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ID Code: 84094
Item Type: QUT Thesis (PhD)
Supervisor: Clements, Judith & Loessner, Daniela
Keywords: Cancer, Degradomics, Transcriptomics, Prostate, Kallikrein-related peptidase, Proteolysis, Tumour microenvironment, Omics, Reactive stroma, Substrate
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 29 Jun 2015 00:28
Last Modified: 08 Sep 2015 05:55

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