Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment
Fuhrman-Luck, Ruth Anna (2015) Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment. PhD thesis, Queensland University of Technology.
Prostate cancer is a leading cause of male cancer-related death and novel therapies are required that prevent progression to terminal disease. This study identified novel protein targets and cell signalling pathways regulated by the prostate cancer-associated protease, kallikrein-related peptidase 4, highlighting it as a promising target for anti-cancer therapy. Seventy-five novel targets and key signalling pathways were identified to be regulated by the protease, suggesting novel functions in remodelling tumour tissue to enable prostate cancer progression.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Clements, Judith & Loessner, Daniela|
|Keywords:||Cancer, Degradomics, Transcriptomics, Prostate, Kallikrein-related peptidase, Proteolysis, Tumour microenvironment, Omics, Reactive stroma, Substrate|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||29 Jun 2015 00:28|
|Last Modified:||08 Sep 2015 05:55|
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