Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide

Reffuveille, Fany, de la Fuente-Núñez, César, Fairfull-Smith, Kathryn E., & Hancock, Robert E.W. (2015) Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide. Pathogens and Disease, 73(5).

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We previously showed that soluble nitroxides (nitric oxide analogues) mimicked the well-established ability of nitric oxide to cause biofilm dispersal and further showed that these compounds could prevent biofilm formation. Here, we investigated the effect of the nitroxide carboxy-TEMPO in combination with sub μg/ml concentrations of ciprofloxacin on pre-formed flow cell biofilms formed by Gram-negative bacteria. Combination therapy led to substantial eradication of existing biofilms formed by Pseudomonas aeruginosa PA14 (99.3%) and Escherichia coli O157 (93%).

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ID Code: 84114
Item Type: Journal Article
Refereed: Yes
DOI: 10.1093/femspd/ftv016
ISSN: 2049-632X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2015 FEMS
Deposited On: 14 May 2015 04:45
Last Modified: 01 Apr 2016 15:59

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