Changes in mood, depression and suicidal ideation after commencing pregabalin for neuropathic pain

Hall, Tony, Shah, Simon, & Ng, Bradley (2014) Changes in mood, depression and suicidal ideation after commencing pregabalin for neuropathic pain. Australian Family Physician, 43(10), pp. 705-708.

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Abstract

Background

Pregabalin is a treatment option for patients with persistent neuropathic pain. Its use has been associated with changes in mood and the development of depression and/or suicidal ideation.

Objective

Case presentations were reviewed of five patients reporting changes in mood, depression and suicidal ideation from the first 50 (approximately) patients commenced on pregabalin at the clinic.

Discussion

Although these patients had a history of depression, their mood had been stable before commencing pregabalin. Soon after commencement they reported changes in mood, and development of depression and/or suicidal ideation, which improved with dose reduction or cessation of pregabalin. Ultimately, all five patients ceased pregabalin treatment. Suicidal ideation is a recog-nised adverse effect of pregabalin. Patients should be warned of and monitored for deterioration in mood.

Impact and interest:

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ID Code: 84369
Item Type: Journal Article
Refereed: Yes
ISSN: 0300-8495
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 Royal Australian College of General Practitioners
Deposited On: 20 May 2015 04:13
Last Modified: 10 Jan 2016 22:54

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