Combination chemotherapy for primary small intestinal lymphoma in the Middle East
El Saghir, Nagi S., Jessen, Klaus, Mass, Robert E., Al-Mofleh, Ibrahim, Santhosh-Kumar, C.R., Hall, Anthony D., & Stuart, Angus E. (1989) Combination chemotherapy for primary small intestinal lymphoma in the Middle East. European Journal of Cancer and Clinical Oncology, 25(5), pp. 851-856.
Twelve patients with primary small intestinal lymphoma were followed prospectively for 3 years. Endoscopic abnormalities were diagnostic of lymphoma in all cases where the duodenum was involved (83%). In three cases (25%) the disease extended to the stomach. One patient (8%) had diffuse small cell cleaved and 11 (92%) diffuse large cell lymphoma stages I (8%), II (25%), III (58%) and IV (8%). Nine of them were unresectable and primarily treated with combination chemotherapy; 67% achieved complete remission, 22% partial response and 11% no response. Only one patient relapsed and achieved a second remission. All complete remission patients are currently alive and free of disease at a median follow-up of 36 months. Overall survival for all patients is 58%, and disease-free survival is 50%. No instance of chemotherapy-related bleeding or perforation was seen. Tetracycline was necessary for the treatment of IPSID-associated diarrhea and malabsorption in spite of cytotoxic chemotherapy.
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|Item Type:||Journal Article|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||21 May 2015 01:29|
|Last Modified:||19 Jun 2015 00:42|
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