Infectious complications during therapy of acute leukaemia in Saudi Arabia

Hall, Anthony, El Saghir, N.S., Santosh-Kumar, C, & Zeitany, R.G. (1989) Infectious complications during therapy of acute leukaemia in Saudi Arabia. Journal of Hospital Infection, 14(3), pp. 209-215.

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In 40 febrile neutropenic episodes during the induction and consolidation chemotherapy of acute leukaemia in Riyadh, 51% of organisms causing septicaemia were gram-negative, 26% gram-positive, 8% anaerobes and 15% fungi. In 21 (52%) febrile episodes there were pulmonary infiltrates; of the 12 where aetiology was known, six were due to fungi. Pulmonary infiltrates progressed to adult respiratory distress syndrome and death in nine instances. There was no significant occurrence of parasitic and tropical infections. The results show that the pattern of infections, during therapy of acute leukaemia in developing countries, may have important differences when compared with western centres. Empiric amphotericin B may need to be introduced at an earlier stage in patients with persistent fever or progressive pulmonary infiltrates.

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ID Code: 84395
Item Type: Journal Article
Refereed: Yes
Keywords: Acute leukaemia, septicaemia, pneumonia, fungal infection
DOI: 10.1016/0195-6701(89)90037-6
ISSN: 1532-2939
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: © 1989 The Hospital Infection Society
Deposited On: 21 May 2015 01:48
Last Modified: 21 May 2015 01:48

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