An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder

Jovev, Martina, Garner, Belinda, Phillips, Lisa, Velakoulis, Dennis, Wood, Stephen J., Jackson, Henry J., Pantelis, Christos, McGorry, Patrick D., & Chanen, Andrew M. (2008) An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging, 162(3), pp. 273-277.

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This structural magnetic resonance imaging study examined the relationship between pituitary gland volume (PGV) and lifetime number of parasuicidal behaviors in a first-presentation, teenage borderline personality disorder (BPD) sample with minimal exposure to treatment. Hierarchical regression analysis revealed that age and number of parasuicidal behaviors were significant predictors of PGV. These findings indicate that parasuicidal behavior in BPD might be associated with greater activation of the hypothalamic-pituitary-adrenal (HPA) axis. Further studies are required using direct neuroendocrine measures and exploring other parameters of self-injurious behavior, such as recency of self-injurious behavior, intent to die and medical threat.

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20 citations in Web of Science®

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ID Code: 84467
Item Type: Journal Article
Refereed: Yes
Keywords: pituitary gland, self-injurious behaviour, adolescence, borderline personality disorder, stress
DOI: 10.1016/j.pscychresns.2007.12.003
ISSN: 0925-4927
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier Ireland Ltd.
Deposited On: 26 May 2015 00:37
Last Modified: 04 Jun 2015 04:42

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