Pituitary volume in teenagers with first-presentation borderline personality disorder

Garner, Belinda, Chanen, Andrew M., Phillips, Lisa, Velakoulis, Dennis, Wood, Stephen J., Jackson, Henry J., Pantelis, Christos, & McGorry, Patrick D. (2007) Pituitary volume in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging, 156(3), pp. 257-261.

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This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n=20) and the total BPD cohort (n=20). However, within the BPD cohort, those exposed to childhood trauma (n=9) tended to have smaller pituitaries (-18%) than those with no history of childhood trauma (n=10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic-pituitary-adrenal axis dysfunction.

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21 citations in Scopus
16 citations in Web of Science®
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ID Code: 84468
Item Type: Journal Article
Refereed: Yes
Keywords: stress, HPA axis, childhood trauma, borderline personality disorder
DOI: 10.1016/j.pscychresns.2007.05.001
ISSN: 0925-4927
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier Ireland Ltd.
Deposited On: 26 May 2015 00:45
Last Modified: 24 Jun 2017 20:01

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