Mesenchymal stem cells as mediators of the neuronal cell niche

Okolicsanyi, Rachel K. (2015) Mesenchymal stem cells as mediators of the neuronal cell niche. PhD thesis, Queensland University of Technology.


This study examined the role of heparan sulfate proteoglycans (HSPGs) in neural lineage differentiation of human mesenchymal stem cells (hMSCs). Several HSPGs were identified as potential new targets controlling neural fate specification and may be applied to the development of improved models to examine and repair brain damage. hMSCs were characterised throughout extended in vitro expansion for neural lineage potential (neurons, astrocytes, oligodendrocytes) and differentiated using terminal differentiation and intermediate sphere formation. Brain damage and neurological disorders caused by injury or disease affect a large number of people often resulting in lifelong disabilities. Multipotent mesenchymal stem cells have a large capacity for self-renewal and provide an excellent model to examine the regulation and contribution of both stem cells and their surrounding microenvironment to the repair of neural tissue damage.

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ID Code: 84485
Item Type: QUT Thesis (PhD)
Supervisor: Haupt, Larisa & Griffiths, Lyn
Additional Information: Embargo requested by the faculty until 31 December 2015.
Keywords: Human Mesenchymal Stem Cells, Heparan Sulfate Proteoglycans, Neural Differentiation, Brain Trauma, Neural Stem Cell, Syndecan, Glypican, Nestin, SOX2, Primary Cell Culture
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 18 Jun 2015 02:42
Last Modified: 31 Dec 2015 14:01

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