Identifying relationships between symptom clusters and quality of life in adults with chronic mixed venous and arterial leg ulcers

Do, Hien Thi Thu, Edwards, Helen, & Finlayson, Kathleen (2016) Identifying relationships between symptom clusters and quality of life in adults with chronic mixed venous and arterial leg ulcers. International Wound Journal, 13(5), pp. 904-911.

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The objective of this study was to identify symptom clusters and their effect on quality of life (QOL) of adults with chronic leg ulcers of mixed venous and arterial aetiology. A secondary analysis of data from four existing prospective longitudinal studies conducted by a wound healing research group in Australia was undertaken. A total of 110 patients who met the inclusion criteria were selected for this study. Exploratory factor analysis (EFA) was used to identify symptom clusters and correlational analyses to examine relationships between the identified symptom clusters and QOL. The EFA identified two distinct symptom clusters: a 'systemic symptom cluster' consisting of pain, fatigue and depressive symptoms; and a 'localised-leg symptom cluster' including pain, fatigue, oedema, lower limb inflammation and exudate. Physical QOL correlated significantly with the systemic symptom cluster (r = -0·055, P < 0·0001) and the localised-leg symptom cluster (r = -0·054, P < 0·0001), whereas mental QOL was associated only with the systemic symptom cluster (r = -0·038, P = 0·01). The results suggest that appropriate intervention strategies targeting specific symptom clusters should be developed. Targeting patients with symptom clusters is particularly important because they are at high risk and the most vulnerable for reduced QOL.

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2 citations in Scopus
4 citations in Web of Science®
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ID Code: 84581
Item Type: Journal Article
Refereed: Yes
Keywords: Chronic leg ulcers, Symptom cluster, Quality of life, Mixed venous and arterial aetiology
DOI: 10.1111/iwj.12405
ISSN: 17424801
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Nursing not elsewhere classified (111099)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2015 Inc and John Wiley & Sons Ltd
Deposited On: 31 May 2015 23:06
Last Modified: 16 Sep 2016 02:49

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