B-adrenoceptor determinants of contractility in the human heart: The role of phosphodiesterase enzymes
Gillette-Browne, Katherine Tegan (2015) B-adrenoceptor determinants of contractility in the human heart: The role of phosphodiesterase enzymes. PhD thesis, Queensland University of Technology.
This thesis investigated how enzymes called phosphodiesterases control changes in contractility mediated by noradrenaline and adrenaline through activation of β1- and β2-adrenoceptors in live human heart tissue from patients with advanced heart failure undergoing transplantation. The study compared patients who had been administered β-blocker medicines metoprolol or carvedilol or no β-blocker treatment. This work helped to further elucidate the complex roles of target receptors and enzymes that are integral to the progression of heart failure, to compare the mechanisms of action of β-blockers currently used to manage heart failure and to identify new drug targets for heart failure treatment.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Molenaar, Peter & Semmler, Annalese|
|Keywords:||β-adrenoceptor, cilostamide, esmolol, heart failure, metoprolol, phosphodiesterase, PDE3, PDE4, rolipram, carvedilol|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||23 Jul 2015 04:20|
|Last Modified:||08 Sep 2015 05:34|
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