B-adrenoceptor determinants of contractility in the human heart: The role of phosphodiesterase enzymes

Gillette-Browne, Katherine Tegan (2015) B-adrenoceptor determinants of contractility in the human heart: The role of phosphodiesterase enzymes. PhD thesis, Queensland University of Technology.


This thesis investigated how enzymes called phosphodiesterases control changes in contractility mediated by noradrenaline and adrenaline through activation of β1- and β2-adrenoceptors in live human heart tissue from patients with advanced heart failure undergoing transplantation. The study compared patients who had been administered β-blocker medicines metoprolol or carvedilol or no β-blocker treatment. This work helped to further elucidate the complex roles of target receptors and enzymes that are integral to the progression of heart failure, to compare the mechanisms of action of β-blockers currently used to manage heart failure and to identify new drug targets for heart failure treatment.

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68 since deposited on 23 Jul 2015
51 in the past twelve months

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ID Code: 84603
Item Type: QUT Thesis (PhD)
Supervisor: Molenaar, Peter & Semmler, Annalese
Keywords: β-adrenoceptor, cilostamide, esmolol, heart failure, metoprolol, phosphodiesterase, PDE3, PDE4, rolipram, carvedilol
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 23 Jul 2015 04:20
Last Modified: 08 Sep 2015 05:34

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