Gene polymorphisms and their effects in the melanocortin system

Carroll, Levi J., Voisey, Joanne, & van Daal, Angela M. (2005) Gene polymorphisms and their effects in the melanocortin system. Peptides, 26(10), pp. 1871-1885.

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Abstract

In addition to its role in human pigmentation, components of the melanocortin system regulate appetite, energy homeostasis and hormone production. Recent studies have suggested possible roles of this system in immunity, transmission of pain signals, and reproductive potential. A number of polymorphisms have been identified in genes of the melanocortin system and are associated with pigmentation in humans, as well as being causative of disorders of adrenal hormone production and obesity. This review gives an outline of these polymorphisms, their functional significance and possible application to or impact on diagnosis and pharmacotherapy based on melanocortin pathways.

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21 citations in Web of Science®

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ID Code: 8471
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Author contact details: j.voisey@qut.edu.au
Keywords: Polymorphism, SNP, Agouti, Melanocortin
DOI: 10.1016/j.peptides.2004.12.031
ISSN: 0196-9781
Divisions: Current > Research Centres > CRC for Diagnostics
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Elsevier
Deposited On: 06 Jul 2007 00:00
Last Modified: 29 Feb 2012 13:13

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