DNA repair pathways and their therapeutic potential in lung cancer

Burgess, Joshua T., Croft, Laura V., Wallace, Nathan C., Stephenson, Sally-Anne, Adams, Mark N., Ashton, Nicholas W., Solomon, Benjamin, O’Byrne, Ken, & Richard, Derek J. (2014) DNA repair pathways and their therapeutic potential in lung cancer. Lung Cancer Management, 3(2), pp. 159-173.

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Abstract

Lung cancer is the leading cause of cancer-related mortality. According to WHO, 1.37 million deaths occur globally each year as a result of this disease. More than 70% of these cases are associated with prior tobacco consumption and/or cigarette smoking, suggesting a direct causal relationship. The development and progression of lung cancer and other malignancies involves the loss of genetic stability, resulting in acquisition of cumulative genetic changes; this affords the cell increased malignant potential. As such, an understanding of the mechanisms through which these events may occur will potentially allow for development of new anticancer therapies. This review will address the association between lung cancer and genetic instability, with a central focus on genetic mutations in the DNA damage repair pathways. In addition, we will discuss the potential clinical exploitation of these pathways, both in terms of biomarker staging, as well as through direct therapeutic targeting.

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ID Code: 84744
Item Type: Review
Refereed: Yes
DOI: 10.2217/lmt.14.12
ISSN: 1758-1974
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 14 Jun 2015 22:30
Last Modified: 14 Jun 2015 22:30

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