Tissue engineering of a morphologically and functionally intact humanized bone organ for bone metastasis research

Holzapfel, Boris Michael (2015) Tissue engineering of a morphologically and functionally intact humanized bone organ for bone metastasis research. PhD by Publication, Queensland University of Technology.


The aim of this thesis was to establish an individualized, patient-specific diagnostic and therapeutic preclinical disease model for bone metastasis research. Tissue engineering of humanized bone within mice allowed the development of a humanized immune system in the host animal. This novel platform makes it possible to analyze the growth of human cancer cells in human bone in the presence of human immune cells.

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29 since deposited on 14 Oct 2015
26 in the past twelve months

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ID Code: 84810
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Hutmacher, Dietmar, Clements, Judith, & Russell, Pamela
Keywords: Tissue Engineering, Bone Metastasis, Cancer Model, Haematopoiesis, Bone Microenvironment, Tumour
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 14 Oct 2015 04:17
Last Modified: 01 Jul 2016 00:16

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