Endurance exercise and DNA stability: Is there a link to duration and intensity?

Reichhold, Stefanie, Neubauer, Oliver, Bulmer, Andrew C., Knasmuller, Siegfried, & Wagner, Karl-Heinz (2009) Endurance exercise and DNA stability: Is there a link to duration and intensity? Mutation Research/Reviews in Mutation Research, 682(1), pp. 28-38.

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It is commonly accepted that regular moderate intensity physical activity reduces the risk of developing many diseases. Counter intuitively, however, evidence also exists for oxidative stress resulting from acute and strenuous exercise. Enhanced formation of reactive oxygen and nitrogen species may lead to oxidatively modified lipids, proteins and nucleic acids and possibly disease. Currently, only a few studies have investigated the influence of exercise on DNA stability and damage with conflicting results, small study groups and the use of different sample matrices or methods and result units. This is the first review to address the effect of exercise of various intensities and durations on DNA stability, focusing on human population studies. Furthermore, this article describes the principles and limitations of commonly used methods for the assessment of oxidatively modified DNA and DNA stability. This review is structured according to the type of exercise conducted (field or laboratory based) and the intensity performed (i.e. competitive ultra/endurance exercise or maximal tests until exhaustion). The findings presented here suggest that competitive ultra-endurance exercise (>4h) does not induce persistent DNA damage. However, when considering the effects of endurance exercise (<4h), no clear conclusions could be drawn. Laboratory studies have shown equivocal results (increased or no oxidative stress) after endurance or exhaustive exercise. To clarify which components of exercise participation (i.e. duration, intensity and training status of subjects) have an impact on DNA stability and damage, additional carefully designed studies combining the measurement of DNA damage, gene expression and DNA repair mechanisms before, during and after exercise of differing intensities and durations are required.

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ID Code: 84824
Item Type: Journal Article
Refereed: Yes
Additional Information: Reichhold, Stefanie
Neubauer, Oliver
Bulmer, Andrew C
Knasmuller, Siegfried
Wagner, Karl-Heinz
Research Support, Non-U.S. Gov't
2009/08/25 09:00
Mutat Res. 2009 Jul-Aug;682(1):28-38. doi: 10.1016/j.mrrev.2009.02.002. Epub 2009 Feb 20.
Keywords: Biological markers, DNA damage, Physical activity, Ultra-endurance exercise
DOI: 10.1016/j.mrrev.2009.02.002
ISSN: 1383-5742
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Nucleic Acids (110105)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Jul 2015 23:09
Last Modified: 27 Jul 2015 00:42

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