No acute and persistent DNA damage after an Ironman triathlon

Reichhold, Stefanie, Neubauer, Oliver, Ehrlich, Veronika, Knasmuller, Siegfried, & Wagner, Karl-Heinz (2008) No acute and persistent DNA damage after an Ironman triathlon. Cancer Epidemiology, Biomarkers and Prevention, 17(8), pp. 1913-1919.

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During acute and strenuous exercise, the enhanced formation of reactive oxygen species can induce damage to lipids, proteins, and nucleic acids. The aim of this study was to investigate the effect of an Ironman triathlon (3.8 km swim, 180 km cycle, 42 km run), as a prototype of ultra-endurance exercise, on DNA stability. As biomarkers of genomic instability, the number of micronuclei, nucleoplasmic bridges, and nuclear buds were measured within the cytokinesis-block micronucleus cytome assay in once-divided peripheral lymphocytes of 20 male triathletes. Blood samples were taken 2 days before, within 20 min after the race, and 5 and 19 days post-race. Overall, the number of micronuclei decreased (P < 0.05) after the race, remained at a low level until 5 days post-race, and declined further to 19 days post-race (P < 0.01). The frequency of nucleoplasmic bridges and nuclear buds did not change immediately after the triathlon. The number of nucleoplasmic bridge declined from 2 days pre-race to 19 days post-exercise (P < 0.05). The frequency of nuclear buds increased after the triathlon, peaking 5 days post-race (P < 0.01) and decreased to basic levels 19 days after the race (P < 0.01). The results suggest that an Ironman triathlon does not cause long-lasting DNA damage in well-trained athletes.

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21 citations in Scopus
6 citations in Web of Science®
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ID Code: 84825
Item Type: Journal Article
Refereed: Yes
Keywords: ultra-endurance exercise, Ironman triathlon, DNA damage, cytokinesis-block micronucleus cytome assay, lymphocytes
DOI: 10.1158/1055-9965.EPI-08-0293
ISSN: 1055-9965
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Nucleic Acids (110105)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Jul 2015 23:03
Last Modified: 24 Jun 2017 23:01

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