DNA damage in response to an Ironman triathlon
Reichhold, Stefanie, Neubauer, Oliver, Hoelzl, Christine, Stadlmayr, Barbara, Valentini, Judit, Ferk, Franziska, Kundi, Michael, Knasmuller, Siegfried, & Wagner, Karl-Heinz (2009) DNA damage in response to an Ironman triathlon. Free Radical Research, 43(8), pp. 753-760.
The major aims of this study were to investigate the effect of an Ironman triathlon on DNA migration in the single cell gel electrophoresis assay, apoptosis and necrosis in the cytokinesis-block micronucleus cytome assay with lymphocytes and on changes of total antioxidant capacity in plasma. Blood samples were taken 2 days (d) before, within 20 min, 1 d, 5 d and 19 d post-race. The level of strand breaks decreased (p<0.05) immediately after the race, then increased (p<0.01) 1 d post-race and declined (p<0.01) until 19 d post-race. Apoptotic and necrotic cells decreased (p<0.01) and the total antioxidant status increased (p<0.01) immediately after the race. The results indicate that ultra-endurance exercise does not cause prolonged DNA damage in well-trained male athletes.
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|Item Type:||Journal Article|
|Keywords:||Apoptosis, DNA damage, Ironman triathlon, Total antioxidant capacity, Ultra-endurance exercise|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Nucleic Acids (110105)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||23 Jul 2015 23:06|
|Last Modified:||27 Jul 2015 01:00|
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