DNA damage in response to an Ironman triathlon

Reichhold, Stefanie, Neubauer, Oliver, Hoelzl, Christine, Stadlmayr, Barbara, Valentini, Judit, Ferk, Franziska, Kundi, Michael, Knasmuller, Siegfried, & Wagner, Karl-Heinz (2009) DNA damage in response to an Ironman triathlon. Free Radical Research, 43(8), pp. 753-760.

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The major aims of this study were to investigate the effect of an Ironman triathlon on DNA migration in the single cell gel electrophoresis assay, apoptosis and necrosis in the cytokinesis-block micronucleus cytome assay with lymphocytes and on changes of total antioxidant capacity in plasma. Blood samples were taken 2 days (d) before, within 20 min, 1 d, 5 d and 19 d post-race. The level of strand breaks decreased (p<0.05) immediately after the race, then increased (p<0.01) 1 d post-race and declined (p<0.01) until 19 d post-race. Apoptotic and necrotic cells decreased (p<0.01) and the total antioxidant status increased (p<0.01) immediately after the race. The results indicate that ultra-endurance exercise does not cause prolonged DNA damage in well-trained male athletes.

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12 citations in Scopus
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13 citations in Web of Science®

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ID Code: 84826
Item Type: Journal Article
Refereed: Yes
Keywords: Apoptosis, DNA damage, Ironman triathlon, Total antioxidant capacity, Ultra-endurance exercise
DOI: 10.1080/10715760903040628
ISSN: 1029-2470
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Nucleic Acids (110105)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Jul 2015 23:06
Last Modified: 27 Jul 2015 01:00

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