Impact of endurance and ultraendurance exercise on DNA damage

Wagner, Karl-Heinz, Reichhold, Stefanie, & Neubauer, Oliver (2011) Impact of endurance and ultraendurance exercise on DNA damage. Annals of the New York Academy of Sciences, 1229, pp. 115-123.

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Abstract

Regular moderate physical activity reduces the risk of several noncommunicable diseases. At the same time, evidence exists for oxidative stress resulting from acute and strenuous exercise by enhanced formation of reactive oxygen and nitrogen species, which may lead to oxidatively modified lipids, proteins, and possibly negative effects on DNA stability. The limited data on ultraendurance events such as an Ironman triathlon show no persistent DNA damage after the events. However, when considering the effects of endurance exercise comparable to a (half) marathon or a short triathlon distance, no clear conclusions could be drawn. In order to clarify which components of exercise participation, such as duration, intensity, frequency, or training status of the subjects, have an impact on DNA stability, more information is clearly needed that combines the measurement of DNA damage, gene expression, and DNA repair mechanisms before, during, and after exercise of differing intensities and durations.

Impact and interest:

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ID Code: 84828
Item Type: Journal Article
Refereed: Yes
Additional Information: Special issue: Nutrition and Physical Activity in Aging, Obesity, and Cancer
Keywords: DNA Damage, Endurance exercise, Physical activity, Training status, Ultraendurance exercise
DOI: 10.1111/j.1749-6632.2011.06106.x
ISSN: 1749-6632
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Nucleic Acids (110105)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Jul 2015 23:02
Last Modified: 27 Jul 2015 01:19

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