Molecular genetic investigation of mitochondrial dysfunction in relation to migraine susceptibility

Stuart, Shani (2015) Molecular genetic investigation of mitochondrial dysfunction in relation to migraine susceptibility. PhD thesis, Queensland University of Technology.

Abstract

The aim of this research was to assess the role of genetic variation in mitochondrial function and how this relates to migraine pathophysiology. Using our unique Norfolk Island population, a custom in-house next generation sequencing methodology was developed. This data for the first time showed that there is a molecular genetic link between mitochondrial dysfunction and migraine susceptibility. This work has provided the foundation for further studies aimed at utilising the identified markers in improved migraine diagnostic and therapeutic strategies.

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93 since deposited on 03 Sep 2015
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ID Code: 84899
Item Type: QUT Thesis (PhD)
Supervisor: Griffiths, Lyn, Lea, Rodney, & Haupt, Larisa
Keywords: Migraine Susceptibility, Mitochondrial Dysfunction, Molecular Genetics, Next Generation Sequencing, Norfolk Island, Ion Torrent, Oxidative Phosphorylation, Haplogroups, Ancestry, Nuclear Encoded Mitochondrial Proteins
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 03 Sep 2015 07:10
Last Modified: 03 Sep 2015 07:10

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