Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke

Hill, M. D., Lye, T., Moss, H., Barber, P. A., Demchuk, A. M., Newcommon, N. J., Green, Theresa L., Kenney, C., Cole-Haskayne, A., & Buchan, A. M. (2003) Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke. Neurology, 60(9), pp. 1525-1527.

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Abstract

One hundred seventy-six consecutive patients treated with IV tissue plasminogen activator (tPA) for acute ischemic stroke were examined prospectively, and orolingual angioedema was found in nine (5.1%; 95% CI 2.3 to 9.5). The reaction was typically mild, transient, and contralateral to the ischemic hemisphere. Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0).

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69 citations in Web of Science®

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ID Code: 85222
Item Type: Journal Article
Refereed: Yes
ISSN: 0028-3878
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Nursing not elsewhere classified (111099)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Deposited On: 08 Jul 2015 23:46
Last Modified: 08 Jul 2015 23:46

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