Identifying the molecular mediators of VN and the IGF:VN complex-stimulated breast cancer cell survival

Shokoohmand, Ali (2015) Identifying the molecular mediators of VN and the IGF:VN complex-stimulated breast cancer cell survival. PhD thesis, Queensland University of Technology.


This project has identified a molecular signature involved in functions critical to breast cancer progression and metastasis mediated by vitronectin, an abundant protein in human plasma and victornectin:insulin-like growth factor complexes. This may have significant implications in designing future therapeutic targets for patient with tumours overexpressing vitronectin and/or the components of the insulin-like growth factor system:vitronectin axis. In particular, the findings from this project have identified Cyr61 and CTGF as key mediators involved in vitroncetin- and insulin-like growth factor I: Insulin-like growth factor-binding protein:vitronectin-induced breast cancer cell survival and migration.

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ID Code: 85436
Item Type: QUT Thesis (PhD)
Supervisor: Hollier, Brett, Upton, Zee, Kashyap, Abhishek, & Van Lonkhuyzen, Derek
Keywords: vitronectin, breast cancer, cancer progression, extracellular matrix, insulin-like growth factor, Attachment, vitronectin-binding integrins
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 28 Jul 2015 02:16
Last Modified: 08 Sep 2015 05:19

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