Identifying the molecular mediators of VN and the IGF:VN complex-stimulated breast cancer cell survival
Shokoohmand, Ali (2015) Identifying the molecular mediators of VN and the IGF:VN complex-stimulated breast cancer cell survival. PhD thesis, Queensland University of Technology.
This project has identified a molecular signature involved in functions critical to breast cancer progression and metastasis mediated by vitronectin, an abundant protein in human plasma and victornectin:insulin-like growth factor complexes. This may have significant implications in designing future therapeutic targets for patient with tumours overexpressing vitronectin and/or the components of the insulin-like growth factor system:vitronectin axis. In particular, the findings from this project have identified Cyr61 and CTGF as key mediators involved in vitroncetin- and insulin-like growth factor I: Insulin-like growth factor-binding protein:vitronectin-induced breast cancer cell survival and migration.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Hollier, Brett, Upton, Zee, Kashyap, Abhishek, & Van Lonkhuyzen, Derek|
|Keywords:||vitronectin, breast cancer, cancer progression, extracellular matrix, insulin-like growth factor, Attachment, vitronectin-binding integrins|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||28 Jul 2015 02:16|
|Last Modified:||08 Sep 2015 05:19|
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