Dielectric properties of proteins from simulation: The effects of solvent, ligands, pH, and temperature
Pitera, Jed W., Falta, Michael, & van Gunsteren, Wilfred F. (2001) Dielectric properties of proteins from simulation: The effects of solvent, ligands, pH, and temperature. Biophysical Journal, 80(6), pp. 2546-2555.
We have used a standard Fröhlich-Kirkwood dipole moment fluctuation model to calculate the static dielectric permittivity, epsilon(0), for four different proteins, each of which was simulated under at least two different conditions of pH, temperature, solvation, or ligand binding. For the range of proteins and conditions studied, we calculate values for epsilon(0) between 15 and 40. Our results show, in agreement with prior work, that the behavior of charged residues is the primary determinant of the effective permittivity. Furthermore, only environmental changes that alter the properties of charged residues exert a significant effect on epsilon. In contrast, buried water molecules or ligands have little or no effect on protein dielectric properties.
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|Item Type:||Journal Article|
|Subjects:||Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)|
|Divisions:||Current > QUT Faculties and Divisions > QUT Business School|
|Copyright Owner:||Copyright 2001 Biophysical Society|
|Copyright Statement:||Reproduced in accordance with the copyright policy of the publisher.|
|Deposited On:||11 Jul 2007|
|Last Modified:||05 Jan 2011 13:32|
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