Brain fiber architecture, genetics, and intelligence: a high angular resolution diffusion imaging (HARDI) study

Chiang, M. C., Barysheva, M., Lee, A. D., Madsen, S., Klunder, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, Greig I., Meredith, M., Wright, M. J., Srivastava, A., Balov, N., & Thompson, P. M. (2008) Brain fiber architecture, genetics, and intelligence: a high angular resolution diffusion imaging (HARDI) study. In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008: 11th International Conference, New York, NY, USA, September 6-10, 2008, Proceedings, Part I, Springer Berlin Heidelberg, New York, USA, pp. 1060-1067.

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We developed an analysis pipeline enabling population studies of HARDI data, and applied it to map genetic influences on fiber architecture in 90 twin subjects. We applied tensor-driven 3D fluid registration to HARDI, resampling the spherical fiber orientation distribution functions (ODFs) in appropriate Riemannian manifolds, after ODF regularization and sharpening. Fitting structural equation models (SEM) from quantitative genetics, we evaluated genetic influences on the Jensen-Shannon divergence (JSD), a novel measure of fiber spatial coherence, and on the generalized fiber anisotropy (GFA) a measure of fiber integrity. With random-effects regression, we mapped regions where diffusion profiles were highly correlated with subjects' intelligence quotient (IQ). Fiber complexity was predominantly under genetic control, and higher in more highly anisotropic regions; the proportion of genetic versus environmental control varied spatially. Our methods show promise for discovering genes affecting fiber connectivity in the brain.

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17 citations in Scopus
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12 citations in Web of Science®

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ID Code: 85698
Item Type: Conference Paper
Refereed: Yes
DOI: 10.1007/978-3-540-85988-8_126
ISBN: 9783540859888
ISSN: 0302-9743
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Springer-Verlag Berlin Heidelberg
Deposited On: 01 Sep 2015 02:46
Last Modified: 03 Sep 2015 03:40

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