Neural correlates of semantic priming for ambiguous words: An event-related fMRI study

Copland, D. A., de Zubicaray, G. I., McMahon, K., & Eastburn, M. (2007) Neural correlates of semantic priming for ambiguous words: An event-related fMRI study. Brain Research, 1131(1), pp. 163-172.

View at publisher


We investigated the neural correlates of semantic priming by using event-related fMRI to record blood oxygen level dependent (BOLD) responses while participants performed speeded lexical decisions (word/nonword) on visually presented related versus unrelated prime-target pairs. A long stimulus onset asynchrony of 1000 ms was employed, which allowed for increased controlled processing and selective frequency-based ambiguity priming. Conditions included an ambiguous word prime (e.g. bank) and a target related to its dominant (e.g. money) or subordinate meaning (e.g. river). Compared to an unrelated condition, primed dominant targets were associated with increased activity in the LIFG, the right anterior cingulate and superior temporal gyrus, suggesting postlexical semantic integrative mechanisms, while increased right supramarginal activity for the unrelated condition was consistent with expectancy based priming. Subordinate targets were not primed and were associated with reduced activity primarily in occipitotemporal regions associated with word recognition, which may be consistent with frequency-based meaning suppression. These findings provide new insights into the neural substrates of semantic priming and the functional-anatomic correlates of lexical ambiguity suppression mechanisms.

Impact and interest:

38 citations in Scopus
Search Google Scholar™
38 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 85713
Item Type: Journal Article
Refereed: Yes
Keywords: fMRI, Lexical ambiguity, Lexical decision, Semantic priming, Suppression
DOI: 10.1016/j.brainres.2006.11.016
ISSN: 1872-6240
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier B.V.
Deposited On: 07 Oct 2015 02:26
Last Modified: 16 Oct 2015 04:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page