Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa

Copland, D. A., McMahon, K. L., Silburn, P. A., & de Zubicaray, Greig I. (2009) Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa. Cerebral Cortex, 19(11), pp. 2651-2658.

View at publisher


There is emerging evidence that alterations in dopaminergic transmission can influence semantic processing, yet the neural mechanisms involved are unknown. The influence of levodopa (L-DOPA) on semantic priming was investigated in healthy individuals (n=20) using event-related functional magnetic resonance imaging with a randomized, double-blind crossover design. Critical prime-target pairs consisted of a lexical ambiguity prime and 1) a target related to the dominant meaning of the prime (e.g., bank-money), 2) a target related to the subordinate meaning (e.g., fence-sword), or 3) an unrelated target (e.g., ball-desk). Behavioral data showed that both dominant and subordinate meanings were primed on placebo. In contrast, there was preserved priming of dominant meanings and no significant priming of subordinate meanings on L-DOPA, the latter associated with decreased anterior cingulate and dorsal prefrontal cortex activity. Dominant meaning activation on L-DOPA was associated with increased activity in the left rolandic operculum and left middle temporal gyrus. These findings suggest that L-DOPA enhances frequency-based semantic focus via prefrontal and temporal modulation of automatic semantic priming and through engagement of anterior cingulate mechanisms supporting attentional/controlled priming.

Impact and interest:

21 citations in Scopus
19 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 85715
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :16
Export Date: 17 July 2015
Keywords: Brain imaging, Dopamine, FMRI, Language, Lexical ambiguity, Semantic priming
DOI: 10.1093/cercor/bhp017
ISSN: 1460-2199
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 The Author
Deposited On: 04 Sep 2015 00:10
Last Modified: 25 Jun 2017 04:02

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page