Heritability of head motion during resting state functional MRI in 462 healthy twins

Couvy-Duchesne, B., Blokland, G. A. M., Hickie, I. B., Thompson, P. M., Martin, N. G., de Zubicaray, Greig I., McMahon, K. L., & Wright, M. J. (2014) Heritability of head motion during resting state functional MRI in 462 healthy twins. NeuroImage, 102(P2), pp. 424-434.

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Abstract

Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% fema≤ 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r=0.53-0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2-=0.23 (sd=0.041), BA45: h2-=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated.

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ID Code: 85716
Item Type: Journal Article
Refereed: Yes
Keywords: Broca's area, Head motion, Heritability, Resting state fMRI, Twin study
DOI: 10.1016/j.neuroimage.2014.08.010
ISSN: 1095-9572
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier Inc.
Deposited On: 07 Sep 2015 06:53
Last Modified: 17 Sep 2015 04:13

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