Left versus right hemisphere differences in brain connectivity: 4-Tesla HARDI tractography in 569 twins
Daianu, M., Jahanshad, N., Dennis, E. L., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Wright, M. J., Hickie, I. B., & Thompson, P. M. (2012) Left versus right hemisphere differences in brain connectivity: 4-Tesla HARDI tractography in 569 twins. In 2012 9th IEEE International Symposium on Biomedical Imaging : From Nano to Macro : proceedings : May 2-5, 2012, Barcelona, Spain, IEEE, Barcelona, Spain, pp. 526-529.
Diffusion imaging can map anatomical connectivity in the living brain, offering new insights into fundamental questions such as how the left and right brain hemispheres differ. Anatomical brain asymmetries are related to speech and language abilities, but less is known about left/right hemisphere differences in brain wiring. To assess this, we scanned 457 young adults (age 23.4±2.0 SD years) and 112 adolescents (age 12-16) with 4-Tesla 105-gradient high-angular resolution diffusion imaging. We extracted fiber tracts throughout the brain with a Hough transform method. A 70×70 connectivity matrix was created, for each subject, based on the proportion of fibers intersecting 70 cortical regions. We identified significant differences in the proportions of fibers intersecting left and right hemisphere cortical regions. The degree of asymmetry in the connectivity matrices varied with age, as did the asymmetry in network topology measures such as the small-world effect.
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|Item Type:||Conference Paper|
|Keywords:||connectome, high angular resolution diffusion imaging (HARDI), laterality, small-world effect, tractography|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 IEEE|
|Deposited On:||21 Oct 2015 04:50|
|Last Modified:||29 Oct 2015 03:43|
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