Motor response suppression and the prepotent tendency to respond: A parametric fMRI study

de Zubicaray, G. I., Andrew, C., Zelaya, F. O., Williams, S. C. R., & Dumanoir, C. (2000) Motor response suppression and the prepotent tendency to respond: A parametric fMRI study. Neuropsychologia, 38(9), pp. 1280-1291.

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Abstract

In the present study we utilised functional magnetic resonance imaging (fMRI) to examine cerebral activation during performance of a classic motor task in which response suppression load was parametrically varied. Linear increases in activity were observed in a distributed network of regions across both cerebral hemispheres, although with more extensive involvement of the right prefrontal cortex. Activated regions included prefrontal, parietal and occipitotemporal cortices. Decreasing activation was similarly observed in a distributed network of regions. These response forms are discussed in terms of an increasing requirement for visual cue discrimination and suppression/selection of motor responses, and a decreasing probability of the occurrence of non-target stimuli and attenuation of a prepotent tendency to respond. The results support recent proposals for a dominant role for the right-hemisphere in performance of motor response suppression tasks that emphasise the importance of the right prefrontal cortex.

Impact and interest:

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105 citations in Web of Science®

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ID Code: 85734
Item Type: Journal Article
Refereed: Yes
Keywords: Functional MRI, Inhibition of prepotent responses, Motor response suppression, Prefrontal cortex
DOI: 10.1016/S0028-3932(00)00033-6
ISSN: 1873-3514
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Elsevier Science Ltd
Deposited On: 07 Oct 2015 06:52
Last Modified: 07 Oct 2015 06:52

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