Meeting the challenges of neuroimaging genetics

de Zubicaray, G. I., Chiang, M. C., McMahon, K. L., Shattuck, D. W., Toga, A. W., Martin, N. G., Wright, M. J., & Thompson, P. M. (2008) Meeting the challenges of neuroimaging genetics. Brain Imaging and Behavior, 2(4), pp. 258-263.

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As research encompassing neuroimaging and genetics gains momentum, extraordinary information will be uncovered on the genetic architecture of the human brain. However, there are significant challenges to be addressed first. Not the least of these challenges is to accomplish the sample size necessary to detect subtle genetic influences on the morphometry and function of the healthy brain. Aside from sample size, image acquisition and analysis methods need to be refined in order to ensure optimum sensitivity to genetic and complementary environmental influences. Then there is the vexing issue of interpreting the resulting data. We describe how researchers from the east coast of Australia and the west coast of America have embarked upon a collaboration to meet these challenges using data currently being collected from a large-scale twin study, and offer some opinions about future directions in the field.

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44 citations in Scopus
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39 citations in Web of Science®

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ID Code: 85736
Item Type: Journal Article
Refereed: No
Keywords: ACE modeling, Genetics, Heritability, High-angular resolution diffusion imaging (HARDI), Neuroimaging
DOI: 10.1007/s11682-008-9029-0
ISSN: 1931-7565
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Springer Science+Business Media LLC
Deposited On: 07 Oct 2015 02:22
Last Modified: 20 Oct 2015 05:28

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