The structure and connectivity of semantic memory in the healthy older adult brain

de Zubicaray, G. I., Rose, S. E., & McMahon, K. L. (2011) The structure and connectivity of semantic memory in the healthy older adult brain. NeuroImage, 54(2), pp. 1488-1494.

View at publisher


The anterior temporal lobes (ATLs) have been proposed to serve as a "hub" linking amodal or domain general information about the meaning of words, objects, facts and people distributed throughout the brain in semantic memory. The two primary sources of evidence supporting this proposal, viz. structural imaging studies in semantic dementia (SD) patients and functional imaging investigations, are not without problems. Similarly, knowledge about the anatomo-functional connectivity of semantic memory is limited to a handful of intra-operative electrocortical stimulation (IES) investigations in patients. Here, using principal components analyses (PCA) of a battery of conceptual and non-conceptual tests coupled with voxel based morphometry (VBM) and diffusion tensor imaging (DTI) in a sample of healthy older adults aged 55-85. years, we show that amodal semantic memory relies on a predominantly left lateralised network of grey matter regions involving the ATL, posterior temporal and posterior inferior parietal lobes, with prominent involvement of the left inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus fibre pathways. These results demonstrate relationships between semantic memory, brain structure and connectivity essential for human communication and cognition.

Impact and interest:

34 citations in Scopus
Search Google Scholar™
31 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 85748
Item Type: Journal Article
Refereed: Yes
Keywords: Anterior temporal lobe, Diffusion tensor imaging, Magnetic resonance imaging, Semantic memory, Small world networks
DOI: 10.1016/j.neuroimage.2010.08.058
ISSN: 1095-9572
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Elsevier Inc
Deposited On: 06 Oct 2015 03:11
Last Modified: 16 Oct 2015 03:12

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page