Prefrontal cortex involvement in selective letter generation: A functional magnetic resonance imaging study

de Zubicaray, G. I., Williams, S. C. R., Wilson, S. J., Rose, S. E., Brammer, M. J., Bullmore, E. T., Simmons, A., Chalk, J. B., Semple, J., Brown, A. P., Smith, G. A., Ashton, R., & Doddrell, D. M. (1998) Prefrontal cortex involvement in selective letter generation: A functional magnetic resonance imaging study. Cortex, 34(3), pp. 389-401.

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Abstract

Cerebral responses to alternating periods of a control task and a selective letter generation paradigm were investigated with functional Magnetic Resonance Imaging (fMRI). Subjects selectively generated letters from four designated sets of six letters from the English language alphabet, with the instruction that they were not to produce letters in alphabetical order either forward or backward, repeat or alternate letters. Performance during this condition was compared with that of a control condition in which subjects recited the same letters in alphabetical order. Analyses revealed significant and extensive foci of activation in a number of cerebral regions including mid-dorsolateral frontal cortex, inferior frontal gyrus, precuneus, supramarginal gyrus, and cerebellum during the selective letter generation condition. These findings are discussed with respect to recent positron emission tomography (PET) and fMRI studies of verbal working memory and encoding/retrieval in episodic memory.

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ID Code: 85751
Item Type: Journal Article
Refereed: No
Keywords: Functional Magnetic Resonance Imaging, Prefrontal cortex, Random generation, Working memory
DOI: 10.1016/S0010-9452(08)70762-7
ISSN: 1973-8102
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1998 Elsevier Masson Sr
Deposited On: 21 Oct 2015 02:16
Last Modified: 21 Oct 2015 02:16

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