Development of insula connectivity between ages 12 and 30 revealed by high angular resolution diffusion imaging

Dennis, E. L., Jahanshad, N., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Hickie, I. B., Toga, A. W., Wright, M. J., & Thompson, P. M. (2014) Development of insula connectivity between ages 12 and 30 revealed by high angular resolution diffusion imaging. Human Brain Mapping, 35(4), pp. 1790-1800.

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Abstract

The insula, hidden deep within the Sylvian fissures, has proven difficult to study from a connectivity perspective. Most of our current information on the anatomical connectivity of the insula comes from studies of nonhuman primates and post mortem human dissections. To date, only two neuroimaging studies have successfully examined the connectivity of the insula. Here we examine how the connectivity of the insula develops between ages 12 and 30, in 307 young adolescent and adult subjects scanned with 4-Tesla high angular resolution diffusion imaging (HARDI). The density of fiber connections between the insula and the frontal and parietal cortex decreased with age, but the connection density between the insula and the temporal cortex generally increased with age. This trajectory is in line with well-known patterns of cortical development in these regions. In addition, males and females showed different developmental trajectories for the connection between the left insula and the left precentral gyrus. The insula plays many different roles, some of them affected in neuropsychiatric disorders; this information on the insula's connectivity may help efforts to elucidate mechanisms of brain disorders in which it is implicated.

Impact and interest:

13 citations in Scopus
14 citations in Web of Science®
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ID Code: 85758
Item Type: Journal Article
Refereed: Yes
Keywords: Development, HARDI, Insula, Structural connectivity, Tractography
DOI: 10.1002/hbm.22292
ISSN: 1097-0193
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Wiley Periodicals, Inc
Deposited On: 02 Sep 2015 23:44
Last Modified: 02 Sep 2015 23:44

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