Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins

Hibar, D. P., Jahanshad, N., Stein, J. L., Kohannim, O., Toga, A. W., Medland, S. E., Hansell, N. K., McMahon, K. L., De Zubicaray, G. I., Montgomery, G. W., Martin, N. G., Wright, M. J., & Thompson, P. M. (2012) Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins. Twin Research and Human Genetics, 15(3), pp. 286-295.

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Abstract

The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27- 1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.

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8 citations in Scopus
8 citations in Web of Science®
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ID Code: 85764
Item Type: Journal Article
Refereed: Yes
Keywords: Alzheimer's disease, GAB2, Imaging genetics, Tensor-based morphometry
DOI: 10.1017/thg.2012.15
ISSN: 1839-2628
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 The Authors
Deposited On: 31 Jul 2015 05:24
Last Modified: 25 Jun 2017 05:01

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