Genetic clustering on the hippocampal surface for genome-wide association studies

Hibar, D. P., Medland, S. E., Stein, J. L., Kim, S., Shen, L., Saykin, A. J., de Zubicaray, G. I., McMahon, K. L., Montgomery, G. W., Martin, N. G., Wright, M. J., Djurovic, S., Agartz, I. A., Andreassen, O. A., & Thompson, P. M. (2013) Genetic clustering on the hippocampal surface for genome-wide association studies. In Mori, Kensaku, Sakuma, Ichiro, Sato, Yoshinobu, Barillot, Christian, & Navab, Nassir (Eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2013: 16th International Conference, Nagoya, Japan, September 22-26, 2013, Proceedings, Part II, Springer Berlin Heidelberg, Nagoya, Japan, pp. 690-697.

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Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene effects are weak and one must also correct for multiple comparisons across the genome and the image. Here we extend recent work on genetic clustering of images, to analyze surface-based models of anatomy using GWAS. We performed spherical harmonic analysis of hippocampal surfaces, automatically extracted from brain MRI scans of 1254 subjects. We clustered hippocampal surface regions with common genetic influences by examining genetic correlations (r(g)) between the normalized deformation values at all pairs of surface points. Using genetic correlations to cluster surface measures, we were able to boost effect sizes for genetic associations, compared to clustering with traditional phenotypic correlations using Pearson's r.

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ID Code: 85766
Item Type: Conference Paper
Refereed: Yes
DOI: 10.1007/978-3-642-40763-5_85
ISBN: 9783642407635
ISSN: 0302-9743
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Springer-Verlag Berlin Heidelberg
Deposited On: 09 Oct 2015 02:56
Last Modified: 21 Oct 2015 02:24

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