Diffusion imaging protocol effects on genetic associations

Jahanshad, N., Kohannim, O., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Hansell, N. K., Montgomery, G. W., Martin, N. G., Wright, M. J., & Thompson, P. M. (2012) Diffusion imaging protocol effects on genetic associations. In 2012 9th IEEE International Symposium on Biomedical Imaging : From Nano to Macro : Proceedings : May 2-5, 2012, Barcelona, Spain, Barcelona, Spain, pp. 944-947.

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Abstract

Large multi-site image-analysis studies have successfully discovered genetic variants that affect brain structure in tens of thousands of subjects scanned worldwide. Candidate genes have also associated with brain integrity, measured using fractional anisotropy in diffusion tensor images (DTI). To evaluate the heritability and robustness of DTI measures as a target for genetic analysis, we compared 417 twins and siblings scanned on the same day on the same high field scanner (4-Tesla) with two protocols: (1) 94-directions; 2mm-thick slices, (2) 27-directions; 5mm-thickness. Using mean FA in white matter ROIs and FA skeletons derived using FSL, we (1) examined differences in voxelwise means, variances, and correlations among the measures; and (2) assessed heritability with structural equation models, using the classical twin design. FA measures from the genu of the corpus callosum were highly heritable, regardless of protocol. Genome-wide analysis of the genu mean FA revealed differences across protocols in the top associations.

Impact and interest:

3 citations in Scopus
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4 citations in Web of Science®

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ID Code: 85782
Item Type: Conference Paper
Refereed: Yes
Keywords: corpus callosum, DTI protocol stability, genome-wide association study, imaging genetics, multi-site analysis
DOI: 10.1109/ISBI.2012.6235712
ISBN: 9781457718571
ISSN: 1945-7928
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 IEEE
Deposited On: 04 Sep 2015 00:17
Last Modified: 06 Sep 2015 23:46

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