Genetics of anisotropy asymmetry: Registration and sample size effects

Jahanshad, N., Lee, A. D., Leporé, N., Chou, Y. Y., Brun, C. C., Barysheva, M., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Wright, M. J., & Thompson, P. M. (2009) Genetics of anisotropy asymmetry: Registration and sample size effects. In Yang, Guang-Zhong, Hawkes, David, Rueckert, Daniel, Noble, Alison, & Taylor, Chris (Eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009: 12th International Conference, London, UK, September 20-24, 2009, Proceedings, Part I, Springer Berlin Heidelberg, London, UK, pp. 498-505.

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Brain asymmetry has been a topic of interest for neuroscientists for many years. The advent of diffusion tensor imaging (DTI) allows researchers to extend the study of asymmetry to a microscopic scale by examining fiber integrity differences across hemispheres rather than the macroscopic differences in shape or structure volumes. Even so, the power to detect these microarchitectural differences depends on the sample size and how the brain images are registered and how many subjects are studied. We fluidly registered 4 Tesla DTI scans from 180 healthy adult twins (45 identical and fraternal pairs) to a geometrically-centered population mean template. We computed voxelwise maps of significant asymmetries (left/right hemisphere differences) for common fiber anisotropy indices (FA, GA). Quantitative genetic models revealed that 47-62% of the variance in asymmetry was due to genetic differences in the population. We studied how these heritability estimates varied with the type of registration target (T1- or T2-weighted) and with sample size. All methods consistently found that genetic factors strongly determined the lateralization of fiber anisotropy, facilitating the quest for specific genes that might influence brain asymmetry and fiber integrity.

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ID Code: 85785
Item Type: Conference Paper
Refereed: Yes
DOI: 10.1007/978-3-642-04271-3_61
ISBN: 9783642042683
ISSN: 0302-9743
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Springer Berlin Heidelberg
Deposited On: 09 Oct 2015 05:50
Last Modified: 21 Oct 2015 01:43

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