Genetics of path lengths in brain connectivity networks: HARDI-based maps in 457 adults
Jahanshad, N., Prasad, G., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Wright, M. J., & Thompson, P. M. (2012) Genetics of path lengths in brain connectivity networks: HARDI-based maps in 457 adults. In Yap, Pew-Thian, Liu, Tianming, Shen, Dinggang, Westin, Carl-Fredrik, & Shen, Li (Eds.) Multimodal Brain Image Analysis: Second International Workshop, MBIA 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 1-5, 2012. Proceedings, Springer-Verlag, Nice, France, pp. 29-40.
Brain connectivity analyses are increasingly popular for investigating organization. Many connectivity measures including path lengths are generally defined as the number of nodes traversed to connect a node in a graph to the others. Despite its name, path length is purely topological, and does not take into account the physical length of the connections. The distance of the trajectory may also be highly relevant, but is typically overlooked in connectivity analyses. Here we combined genotyping, anatomical MRI and HARDI to understand how our genes influence the cortical connections, using whole-brain tractography. We defined a new measure, based on Dijkstra's algorithm, to compute path lengths for tracts connecting pairs of cortical regions. We compiled these measures into matrices where elements represent the physical distance traveled along tracts. We then analyzed a large cohort of healthy twins and show that our path length measure is reliable, heritable, and influenced even in young adults by the Alzheimer's risk gene, CLU.
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|Item Type:||Conference Paper|
|Keywords:||Dijkstra's algorithm, HARDI tractography, neuroimaging genetics, path length, Structural connectivity|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 Springer-Verlag|
|Deposited On:||23 Oct 2015 01:40|
|Last Modified:||29 Oct 2015 02:51|
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