Genetics of path lengths in brain connectivity networks: HARDI-based maps in 457 adults

Jahanshad, N., Prasad, G., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Wright, M. J., & Thompson, P. M. (2012) Genetics of path lengths in brain connectivity networks: HARDI-based maps in 457 adults. In Yap, Pew-Thian, Liu, Tianming, Shen, Dinggang, Westin, Carl-Fredrik, & Shen, Li (Eds.) Multimodal Brain Image Analysis: Second International Workshop, MBIA 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 1-5, 2012. Proceedings, Springer-Verlag, Nice, France, pp. 29-40.

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Brain connectivity analyses are increasingly popular for investigating organization. Many connectivity measures including path lengths are generally defined as the number of nodes traversed to connect a node in a graph to the others. Despite its name, path length is purely topological, and does not take into account the physical length of the connections. The distance of the trajectory may also be highly relevant, but is typically overlooked in connectivity analyses. Here we combined genotyping, anatomical MRI and HARDI to understand how our genes influence the cortical connections, using whole-brain tractography. We defined a new measure, based on Dijkstra's algorithm, to compute path lengths for tracts connecting pairs of cortical regions. We compiled these measures into matrices where elements represent the physical distance traveled along tracts. We then analyzed a large cohort of healthy twins and show that our path length measure is reliable, heritable, and influenced even in young adults by the Alzheimer's risk gene, CLU.

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ID Code: 85787
Item Type: Conference Paper
Refereed: Yes
Keywords: Dijkstra's algorithm, HARDI tractography, neuroimaging genetics, path length, Structural connectivity
DOI: 10.1007/978-3-642-33530-3_3
ISBN: 9783642335303
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Springer-Verlag
Deposited On: 23 Oct 2015 01:40
Last Modified: 29 Oct 2015 02:51

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