4D deformation modeling of cortical disease progression in Alzheimer's dementia

Janke, Andrew L., de Zubicaray, Greig, Rose, Stephen E., Griffin, Mark, Chalk, Jonathan B., & Galloway, Graham J. (2001) 4D deformation modeling of cortical disease progression in Alzheimer's dementia. Magnetic Resonance in Medicine, 46(4), pp. 661-666.

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This work describes the development of a model of cerebral atrophic changes associated with the progression of Alzheimer's disease (AD). Linear registration, region-of-interest analysis, and voxel-based morphometry methods have all been employed to elucidate the changes observed at discrete intervals during a disease process. In addition to describing the nature of the changes, modeling disease-related changes via deformations can also provide information on temporal characteristics. In order to continuously model changes associated with AD, deformation maps from 21 patients were averaged across a novel z-score disease progression dimension based on Mini Mental State Examination (MMSE) scores. The resulting deformation maps are presented via three metrics: local volume loss (atrophy), volume (CSF) increase, and translation (interpreted as representing collapse of cortical structures). Inspection of the maps revealed significant perturbations in the deformation fields corresponding to the entorhinal cortex (EC) and hippocampus, orbitofrontal and parietal cortex, and regions surrounding the sulci and ventricular spaces, with earlier changes predominantly lateralized to the left hemisphere. These changes are consistent with results from post-mortem studies of AD.

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63 citations in Web of Science®

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ID Code: 85789
Item Type: Journal Article
Refereed: Yes
Keywords: Alzheimer's disease, Average models, MRI, Non-linear registration, Talairach space
DOI: 10.1002/mrm.1243
ISSN: 0740-3194
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 Wiley-Liss, Inc.
Deposited On: 18 Aug 2015 03:05
Last Modified: 18 Aug 2015 03:05

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