Heritability of white matter fiber tract shapes: A HARDI study of 198 twins

Jin, Y., Shi, Y., Joshi, S. H., Jahanshad, N., Zhan, L., de Zubicaray, G. I., McMahon, K. L., Martin, N. G., Wright, M. J., Toga, A. W., & Thompson, P. M. (2011) Heritability of white matter fiber tract shapes: A HARDI study of 198 twins. In Liu, Tianming, Shen, Dinggang, Ibanez, Luis, & Tao, Xiaodong (Eds.) Multimodal Brain Image Analysis: First International Workshop, MBIA 2011, Held in Conjunction with MICCAI 2011, Toronto, Canada, September 18, 2011. Proceedings, Springer Berlin Heidelberg, Toronto, Canada, pp. 35-43.

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Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20-30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps.

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ID Code: 85790
Item Type: Conference Paper
Refereed: Yes
Keywords: Clustering, Curve Matching, Fiber Alignment, HARDI, Heritability, Image Registration, Tractography, White Matter Probabilistic Atlas
DOI: 10.1007/978-3-642-24446-9_5
ISBN: 9783642244469
ISSN: 0302-9743
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Springer-Verlag
Deposited On: 23 Oct 2015 02:56
Last Modified: 29 Oct 2015 03:19

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