The contribution of genes to cortical thickness and volume

Joshi, A. A., Leporé, N., Joshi, S. H., Lee, A. D., Barysheva, M., Stein, J. L., McMahon, K. L., Johnson, K., de Zubicaray, G. I., Martin, N. G., Wright, M. J., Toga, A. W., & Thompson, P. M. (2011) The contribution of genes to cortical thickness and volume. NeuroReport, 22(3), pp. 101-105.

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We analyzed brain MRI data from 372 young adult twins toidentify cortical regions in which gray matter thickness and volume are influenced by genetics. This was achieved using an A/C/E structural equation model that divides the variance of these traits, at each point on the cortex, into additive genetic (A), shared (C), and unique environmental (E) components. A strong genetic influencewas found in frontal and parietal regions. Inaddition, we correlated cortical thickness with full-scale intelligence quotient for comparison with the A/C/E maps, and several regions where cortical structure was correlated with intelligence quotient are under genetic control. These cortical measures may be useful phenotypes to narrow the searchfor quantitative trait lociinfluencing brain structure.

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ID Code: 85795
Item Type: Journal Article
Refereed: No
Keywords: Brain, cortex, genetics, image analysis, magnetic resonance imaging
DOI: 10.1097/WNR.0b013e3283424c84
ISSN: 1473-558X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Deposited On: 07 Oct 2015 02:11
Last Modified: 20 Oct 2015 05:14

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